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Title: A 3D-printable composite for bone-regeneration implants for paediatric maxillofacial reconstruction
Author: Orozco-Díaz, Amnael
ISNI:       0000 0005 0287 5879
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2019
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Autografted cancellous bone is the current gold-standard for maxillofacial reconstruction surgery (MRS), where it is used to fill in small defects. These grafts still pose several drawbacks, including the need for an additional surgical wound at the grafting site, and inadequate bone density at the repaired site. Both situations can have chronic medical and surgical implications, especially in paediatric patients since they are still growing. Cancellous bone, additionally, is not structural, so its applications are limited to non-load bearing sites. This research aimed to developing a bone regeneration material for 3D-printing, which could potentially address these issues. A polylactic acid (PLA) and hydroxyapatite (HA) composite was developed, which is usable in commercialgrade Fused Filament Fabrication (FFF) 3D-printers. FFF allows for the reproduction of any geometry necessary to treat a given bone lesion. PLA provides a biocompatible and resorbable structure for the material, while HA works as a functionalisation agent to induce a cellular response. These composites were studied for mechanical, chemical, thermal, and degradation properties as per ISO-10993-13-2010. In vitro biocompatibility for the material included cell-viability and extracellular-matrix deposition using the MG63 cell line. The composite behaved as expected during characterisation, and was also found to perform equivalent to tissue-culture plastic in regards to in vitro biocompatibility. Degradation results showed that 3D-printing of these materials will likely result in faster in vivo resorption than current PLA implants, and a mathematical model was proposed from these results. This research suggests that 3D-printable PLA-HA composites are a viable material for therapeutic implants for bone-regeneration.
Supervisor: Miller, Cheryl Ann ; Moorehead, Robert ; Reilly, Gwendolen ; Gilchrist, Fiona Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available