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Title: The study of the effectiveness of particles in radiation therapy using GEANT4 simulation
Author: Thongjerm, Piyanud
ISNI:       0000 0005 0287 0066
Awarding Body: University of Huddersfield
Current Institution: University of Huddersfield
Date of Award: 2020
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This thesis describes a Monte-Carlo based simulation study in order to investigate the impact of radiation quality especially linear energy transfer (LET) on the damage of living cell induced by radiation. In this study, the simplified target is used for determining the pattern of the energy deposition of charged particles at different energies in macroscopic level by using Geant4 toolkit. This study highlights the factor that may cause the erroneous LET calculation when using small target in the model. It is shown that although LET is used as a universal term to describes radiation quality, its stochastic nature causes uncertainty when incorporating with biological outcome. In addition, the structural DNA model is used to quantify a number of radiation-induced DNA damage in microscopic level by incorporating with spatial distribution of energy deposition. It is important to note that the number of DNA damage is significantly dependent on adjustable parameters in the simulation including energy threshold for inducing the damage. Finally, the experimental database, PIDE, of various cell types and particles allows investigating the factors including type of cell and particle that influence biological effect.
Supervisor: Barlow, Roger Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: R Medicine (General) ; RC0254 Neoplasms. Tumors. Oncology (including Cancer)