Use this URL to cite or link to this record in EThOS:
Title: Investigating the impact of a spinal mobilisation intervention in people with multiple sclerosis
Author: Hamilton, Rebecca Isabel
ISNI:       0000 0005 0286 4205
Awarding Body: Edinburgh Napier University
Current Institution: Edinburgh Napier University
Date of Award: 2020
Availability of Full Text:
Access from EThOS:
Access from Institution:
Background: Multiple Sclerosis (MS) has many disabling symptoms due to weakened signal propagation in the central nervous system. Manual therapeutics are often seen to have a positive effect on these symptoms with limited information as to why. The purpose of this project was to investigate a spinal mobilisation intervention, objectively measuring the changes it may be causing to muscle quality and movement patterns as a contribution to research in MS therapeutics. Methods: A series of 3 studies were designed to investigate the effects of a spinal mobilisation intervention on muscle quality and movement patterns. Study 1 tested people with lower back pain (LBP) as a pilot population (n=40), testing for an immediate effect on muscle quality. Study 2 replicated this with MS patients (n=20) assessing muscle quality, balance, and pain. Study 3 tested the intervention in a longer-term 4 bout study (n=20), assessing muscle quality, balance, pain, and fatigue. Results: Significant muscle stiffness reductions were seen in the LBP population post the intervention (p = 0.01, η2partial = 0.15). Baseline stiffness was found as a significant contributor (p = 0.002, R2 = 0.22). These muscular results were not replicated with the MS population. However, significant improvements in self-reported pain as a result of the intervention were revealed (p = 0.008, η2partial = 0.33). Study 3 findings demonstrated significant improvements from baseline in balance and fatigue measures as a result of the intervention. High variability in the data are seen within the MS population. Conclusions: Four sessions were not sufficient to elicit a significant response in muscle quality as a result of the intervention in an MS population. However, significant improvements in balance and fatigue were revealed. Given the variability from the MS population, it is necessary to undertake a longer-term study and normalise baseline muscle quality values.
Supervisor: Brown, Susan Sponsor: Medical Research Scotland
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
Keywords: Multiple Sclerosis (MS) ; spinal mobilisation intervention ; muscle quality ; movement patterns ; therapeutics