Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.821459
Title: In-vitro investigation of nitrogen-doped titanium dioxide as an antimicrobial filler in polymeric bonding agents
Author: Ahmad Fauzi, N. A.
ISNI:       0000 0004 9359 4660
Awarding Body: University of Bristol
Current Institution: University of Bristol
Date of Award: 2020
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Abstract:
Aim: To develop a novel aesthetic resin composite using a nitrogen-doped titanium dioxide (N-TiO2) filler that possesses photocatalytic antimicrobial properties against cariogenic bacteria. Setting: Biomaterials and oral microbiology laboratories, Bristol Dental School. Design: In-vitro study to produce an aesthetic composite resin, with long-term antimicrobial properties under visible light. This was done by incorporating a N-TiO2 filler within the resin. Methods: N-TiO2 powder was manufactured by heating commercial TiO2 with urea. Free radical release from the N-TiO2 powder under visible light irradiation was analysed using spectrophotometry. The N-TiO2 powder was incorporated into dental resin and the photocatalytic activity assessed using a dye under both visible light and dark conditions. Using XTT assay to measure the cellular metabolic activity, the antibacterial properties of the N-TiO2 within the resin discs were tested against cariogenic bacteria. Results: Doping nitrogen into TiO2 resulted in a band gap shift towards the visible light spectrum, which enabled the compound to release reactive oxygen species when exposed to visible light. When incorporated into dental resin, the N-TiO2 still demonstrated sustained release of reactive oxygen species, maintaining its photocatalytic activity and showing an antibacterial effect towards Streptococcus mutans under visible light conditions. Conclusions: N-TiO2 filled resin showed great promise as a potential aesthetic resin-based adhesive for orthodontic bonding.
Supervisor: Ireland, Tony ; Su, Bo ; Bandara, Nihal Sponsor: Not available
Qualification Name: Thesis (D.D.S.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.821459  DOI: Not available
Keywords: Titanium dioxide ; orthodontics ; Bonding agents ; White spot lesion
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