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Title: Inhibitory motor processes during movement preparation
Author: Laksanaphuk, Chotica
ISNI:       0000 0004 9359 111X
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2020
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The experiments presented in this thesis investigated the cortical inhibitory mechanisms mediated during the movement preparation. This was examined using response time tasks including the informative pre-cueing stimuli and conflict stimuli. The dual-coil paired-pulse transcranial magnetic stimulation (TMS) technique was used to measure the interhemispheric inhibition (IHI) occurred in both dominant and non-dominant hemispheres. The novel method of substitutional IHI measurement with the stimulus intensity to elicit the motor evoke potential of 1 mV in both hemispheres could elicit the comparable IHI in both hemispheres at rest as reported in other previous IHI studies. There was no lateralized effect of the IHI at rest. The novel method of IHI was further used to explore the cortical inhibition occurred in the motor cortex during movement preparation. It was found that the inhibition observed in the motor cortex contralateral and ipsilateral to the selected hand in order to prevent the premature response and inhibit the unwanted movement were not mediated by the opposite motor cortex. The role of movement preparatory inhibition under the conflict condition was further investigated with the response time, EEG and single pulse TMS when the potential responses were manipulated into the homologous and non-homologous response-modes. The amount of preparatory inhibition to suppress the incorrect response induced by the conflict stimuli was influenced by the response-mode as observed in the response time, EEG, and TMS. The role of movement preparatory inhibition onto motor cortices was discussed in light of these results.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Q Science (General)