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Title: Manipulation of mesenchymal stem cell differentiation via gold nanoparticle-mediated delivery of antagomiRs
Author: Mathew, Shijoy
ISNI:       0000 0004 9356 1113
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 2020
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The human body is a complex piece of organic machinery, and as such, can be prone to faults and deterioration. There are many medical conditions that can be attributed to bone or cartilage deterioration and damage, like osteoarthritis and osteoporosis. Regeneration of these tissues is an on-going challenge, which have been targeted in many different ways. MicroRNAs are short sequenced RNAs that are involved in the regulation of nearly 60 percent of the genes in the body. This project aims to exploit their function to promote differentiation into bone, fat or cartilage cells. This is achieved using nanoparticles as the delivery platform. The use of nanoparticles in medicine has picked up at a rapid rate, and its small size, non-toxicity and multi-valancy allows for a safer and customizable method of cargo delivery. A novel form of inducing osteogenesis is the using of nanovibrations, known as nanokicking. This project aims to use antagomirs or anti-microRNAs as the primary cargo, which is a nucleotide sequence that can bind to the microRNA, causing a loss of function. A combination of nanokicking and functionalised GNP treatment will be used to see if there is an improvement in the efficacy and time taken for differentiation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available