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Title: Reactions of ene-sulfonamides with electron-deficient carbenes
Author: Spreadbury, Samuel Richard John
ISNI:       0000 0004 9350 0054
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2020
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This thesis is divided into three chapters. Chapter one provides a discussion into the stabilisation and reactivity of carbene and carbenoid intermediates. A review of cyclopropanes and cyclopropanation methods is then presented and select synthetic applications of aminocyclopropanes are discussed. Chapter two details investigations of the addition of dihalocarbenes to enantiomerically pure ene-sulfonamides and features the ring-expansion and functionalisation of these substrates. An exploration of the reactivity of cyclic ene-sulfonamides with metal carbenoids is then presented. Chapter three provides experimental procedures and characterisation data for the synthesised compounds.
Supervisor: Craig, Donald Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral