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Title: The role of vitamin D and the vitamin D receptor in skeletal muscle function and exercise adaptation
Author: Ashcroft, Stephen Paul
ISNI:       0000 0004 9346 9712
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2020
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Vitamin D deficiency remains prevalent throughout the world, with severe deficiencies resulting in skeletal muscle myopathies. Within skeletal muscle, a dynamic network of mitochondria exists primarily functioning to produce ATP via oxidative phosphorylation. Recent investigations have proposed that vitamin D related metabolites are able to modulate mitochondrial function within skeletal muscle cell lines and human populations with severe vitamin D deficiencies. Therefore, the aims of this thesis were to further explore the role of vitamin D related signalling via the VDR and diet-induced vitamin D deficiency in modulating skeletal muscle mitochondrial function. It was demonstrated that a reduction in the VDR significantly reduced mitochondrial respiration in the C2C12 skeletal muscle cell line without altering mitochondrial protein content. Furthermore, in vivo investigations revealed a reduction in skeletal muscle mitochondrial respiration following 3-months of diet-induced vitamin D deficiency in mice. Finally, we also demonstrated an impairment in voluntary wheel running performance and the subsequent adaptive response following diet-induced vitamin D deficiency in mice. In summary, this thesis contributes novel data towards the understanding of the role of the vitamin D and the VDR in modulating skeletal muscle mitochondrial function.
Supervisor: Not available Sponsor: MRC
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QP Physiology