Use this URL to cite or link to this record in EThOS:
Title: Application of laser-interfaced mass spectrometry to biological and pharmaceutical molecules
Author: Cercola, Rosaria
ISNI:       0000 0004 8510 8087
Awarding Body: University of York
Current Institution: University of York
Date of Award: 2019
Availability of Full Text:
Access from EThOS:
Full text unavailable from EThOS. Thesis embargoed until 19 Feb 2025
Access from Institution:
This thesis demonstrates the use of laser photodissociation spectroscopy to explore the photochemistry of molecular and cluster ions isolated in a commercially adapted mass spectrometer. Chapter 3 describes gas-phase photodissociation experiments on adenosine nucleotides with phosphate chains of varying lengths with single and double negative charges. Direct comparison between the photochemistry of this series of compounds shows that the adenine π → π* transition is relatively unaffected by the charge state. In addition, the experiments show that photostability is enhanced as the number of phosphate groups increases. Near-threshold excitation of I-·A and H2PO3-·A is investigated in Chapter 4 to explore whether it leads to electron transfer from the anion to the adenine. It is shown that the adenine dipole-bound excited state is prepared from excitation of I-·A. In contrast, electron detachment in H2PO3-·A occurs from the neutral nucleobase and not from the anion. We identify H2PO3-·A as an example of an anion-molecule cluster where photodetachment initiates intra-molecular hydrogen atom transfer. Chapters 5 and 6 describe the application of photodissociation spectroscopy to organometallic complexes for CO-releasing applications.
Supervisor: Dessent, Caroline Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available