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Title: Host resistance and staphylococcal infection
Author: Smith, J. Maclean
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1956
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The host response to infection by staphylococci has been studied by death rates, histological studies and the fate of the cocci in the tissues. Different strains of staphylococci have shown a spectrum of virulence detected by quantitative differences in their multiplication in the kidney. When the host metabolism is disturbed by fasting, fasting with glucose solutions to drink or by increased metabolic activity caused by thyroid hormone or dinitrophenol then the animals are more susceptible to staphylococcal infection. Lactate solution given by mouth to fasted animals is beneficial in correcting the susceptibility to infection caused by fasting. Undernutrition, the result of protein or caloric restriction, does not affect the susceptibility of mice to staphylococcal infection. Renal disease is related to death in human cases of staphylococcal infection. It is possible that a mouse virulence test for staphylococci can be developed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available