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Title: The use of conducting polymer films for drug release device applications
Author: Al Shammary, Badr
ISNI:       0000 0004 8509 7525
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2016
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The aim of this project was to develop electrodes that allow drugs to be uploaded and released from conductive polymer films for biomedical applications. A thorough literature review of conducting polymer synthesis, analysis and doping mechanisms was presented and the applications of conducting polymers in the development of drug delivery systems were reviewed. Electrochemical deposition of polyppyrrole (PPy) was carried out on different susbstrates,including stainless steel (SS), cellulose acetate membranes, AZ31 Mg alloy and hybrid systems. A series colorant and model drugs, such as rhodhamine 6G (Rh-6G), fluoresce in sodium salt (FSS), methylene blue (MB), dopamine hydrochloride (DB), ibuprofen sodium salt (IP), were incorporated into PPy films grown on different substrates and the kinetics of drug release were investigated. The AZ31 Mg alloy was used to investigate self-powered systems. The results presented about this topic include the liberation of IP and sodium salicylate from PPy films deposited on AZ31 Mg alloy. The presence of drugs uploaded into the system, such as IP and salicylate affect the nucleation and growth processes. SEM micrographs of PPy films show a less compact, cracked, uneven surface with needle-like structures observed for sodium ibuprofen containing solutions (>5 mmol dm-3). Self-powered IP release experiments in 0.9% wt. NaCl are fitted to Avrami's equation and the rate variations being attributed to uneven corrosion of the underlying alloy. Mechanical properties such as hardness and reduced modulus decreased 54% and 40% respectively for PPy films prepared in salicylate solutions compared with those prepared in solutions containing different ibuprofen concentration (0.5 to 10 mmol dm-3),indicating a more plastic film with IP. Other results presented include the release of fluorescent dyes and drugs deposited in cellulose membranes covered with magnesium PPy or deposited on SS substrate.
Supervisor: Ponce De Leon Albarran, Carlos Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available