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Title: Development of copper-catalysed addition reactions to alkynes
Author: Tan, Qian Wen
ISNI:       0000 0004 8507 1835
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2020
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In this thesis, new copper-catalysed addition reactions to alkynes have been developed. The new methodologies exploit hydro-functionalisation to transform readily available starting materials into N-heterocycles and enol esters via addition of amides and acids to alkynes, respectively. Chapter 1 is a literature review covering the transition metal-catalysed hydroamination and hydro-oxycarbonylation of alkynes, and some of the well-known copper-catalysed reactions. Chapter 2 documents our new methodology on exploiting the copper-catalysed hydroamination of terminal alkynes to synthesis 5-ylidenepyrrol-2(5H)-ones and 5-hydroxypyrrol-2(5H)-ones, using readily available α-keto amides and terminal alkynes. A method towards the synthesis of asymmetric maleimides is also reported.
Supervisor: Willis, Michael Sponsor: Engineering and Physical Sciences Research Council ; Agency for Science ; Technology and Research
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available