Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.799190
Title: Translational requirements for manufactured dopaminergic neurons for the treatment of Parkinson's disease
Author: Kusena, James
ISNI:       0000 0004 8510 0237
Awarding Body: Loughborough University
Current Institution: Loughborough University
Date of Award: 2019
Availability of Full Text:
Access from EThOS:
Access from Institution:
Abstract:
After decades of research there is now a plethora of cell-based therapies traversing through different phases of clinical trials. However, there remains work to be done regarding optimising the quality and production efficiency of these therapies, as well as economic considerations to validate their commercial viability. This project focuses on the process development of a candidate human embryonic stem cell (hESC) based therapy for Parkinson's disease (PD) and the related health economics. This work set out to identify the key translational requirements for successful, robust and reproducible manufacture of a cell-based therapy for PD, by optimising a preclinical validated differentiation protocol.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.799190  DOI:
Keywords: regenerative cell therapy ; Parkinson's Disease ; Health Economic Evaluation Studies ; bioprocesses
Share: