Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.798971
Title: The relationship between lifestyle factors and neurodegeneration in midlife as expressed on arterial spin labelling and structural magnetic resonance imaging
Author: Topiwala, Hinesh
ISNI:       0000 0004 8509 2716
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 2020
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Abstract:
Introduction: Studies have demonstrated a relationship between neurodegeneration and lifestyle factors. Neurodegeneration in midlife (40 - 59 years old) can be assessed using neuroimaging. The aim of the thesis was to evaluate the relationship between lifestyle factors and neurodegeneration in midlife as expressed on arterial spin labelling and structural magnetic resonance imaging. Methods: A systematic review of the relationship between lifestyle and neurodegeneration in midlife as expressed on functional magnetic resonance imaging (fMRI) was undertaken. Additionally, the impact of lifestyle on the arterial spin labelling (ASL) and structural magnetic resonance imaging (sMRI) expression of neurodegeneration in a midlife cohort was analytically assessed. Results: Seven lifestyle factors associated with neurodegeneration in midlife as expressed on fMRI were identified by the systematic review. Using data from the PREVENT Dementia cohort, linear regression analysis demonstrated multiple associations between lifestyle and neurodegeneration in midlife as expressed on ASL and sMRI. Discussion: The findings from this thesis can guide future analysis of PREVENT Dementia cohort data. Furthermore, the findings from this thesis could be shared with the public through the NHS Health Check in England and the Keep Well Programme in Scotland, to help promote lifestyle interventions to optimise brain health in midlife.
Supervisor: Ritchie, Craig ; Muniz Terrera, Graciela Sponsor: European Commission
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.798971  DOI:
Keywords: neurodegeneration ; neuroprotection ; Magnetic Resonance Imaging ; life style ; middle aged
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