Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.798597
Title: Using pharmacological reconsolidation-interference strategies to attenuate maladaptive appetitive memories
Author: Walsh, Katie
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2019
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Abstract:
Under certain conditions memories can re-enter a transient, labile state in which they are susceptible to modification. 'Reconsolidation' thus describes the hypothetical process by which a reactivated memory is returned to a stable state. The current thesis will explore the potential of pharmacological reconsolidation-interference strategies in attenuating the maladaptive appetitive memories underlying alcohol dependence and binge eating disorder (BED). Chapter 1 presents an overview of the reconsolidation literature and its potential to treat disorders of maladaptive appetitive memory. In Chapter 2, a review and meta-analysis of the efficacy of treatments utilising behavioral and pharmacological reconsolidation strategies in clinical or sub-clinical populations is presented. In Chapter 3, the requirement for the inclusion of a prediction error (PE) at retrieval in a population of hazardous drinkers is assessed in a randomised, between subjects design (N=60). Although no effect of post-retrieval N2O (a predicted blocker of reconsolidation) was observed initially, exploratory analysis showed a memory-weakening effect only when administration occurred after cue-alcohol retrieval and PE. Chapter 4 presents a single blind, randomised, between subjects (N=90) study of the efficacy of the NMDA receptor antagonist ketamine. Relative to placebo and a no-reactivation group, ketamine produced significant reductions in drinking and putative measures of cue-alcohol memory strength. Chapter 5 explores the efficacy of rapamycin, a proven blocker of reconsolidation in pre-clinical models, to attenuate non-drug reward memory in a population with a tendency of overeat or binge on chocolate (N=75). No effect of rapamycin was observed, although this may represent the limited scope to see improvement in measures of disordered eating within this sample. Finally, Chapter 6 summaries and integrates the current findings into the existing literature. A discussion of the implications, limitations, and suggestions for future research on reconsolidation is given.
Supervisor: Kamboj, S. ; Das, R. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.798597  DOI: Not available
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