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Title: The effect of traumatic brain injury on the neuronal cytoskeleton and the axolemma
Author: Fitzpatrick, Michael Owen
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1997
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Head injuries are a major cause of morbidity and mortality in western society. Despite advances in the detection and management of head injury there has been limited improvements in outcome. It is clear that a better understanding of the pathophysiology of traumatic brain injury is essential. Without this scientific basis, the future for patients sustaining severe head injuries remains bleak. The neuronal cytoskeleton consists of proteins which serve structural and functional roles within the neurone. Microtubules are a major component of the cytoskeleton and are essential for normal neuronal functioning. Specifically, they are intimately involved in the process of fast axoplasmic transport in which proteins and organelles are transported from the neuronal cell body to synapses. Disruption of this process may be important in the pathogenesis of traumatically induced neuronal injury. It is hypothesised that alterations in the cytoskeletal framework may represent a common final pathway in the mediation of traumatic insults in the brain. Therefore, elucidation of the mechanisms involved in this process would provide valuable information which could be used in the design of future therapeutic strategies.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available