Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.796935
Title: The control of ductus arteriosus smooth muscle contractility : studies on the physiological and pharmacological properties of the isolated fetal rabbit ductus arteriosus
Author: Smith, Gordon C. S.
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1994
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Abstract:
1. This work studied the smooth muscle of the rabbit ductus arteriosus. The ductus is a shunt blood vessel of the fetus which extends between the main pulmonary artery and aorta and closes after birth. 2. This work had the following aims regarding the isolated fetal rabbit ductus arteriosus (a) to characterise the ideal experimental conditions for study of the vessel; (b) to characterise the dilator prostanoid receptors on the vessel; (c) to characterise the effect of prostaglandin E2 (PGE2) on the response of the vessel to noradrenaline; (d) to characterise the effect of indomethacin on the response of the vessel to PGE2 and other vasodilators; (e) to characterise the effect of oxygen tension on both the response of the vessel to the contractile effect of noradrenaline and the relaxant effect of PGE2 and other vasodilators; and, (f) to characterise contractile effects of prostanoids on the vessel.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.796935  DOI: Not available
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