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Title: Synthetic studies directed towards the sesquiterpenoid grimaldone
Author: Calderwood, David John
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1993
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An advanced intermediate in a route to the odoriferous sesquiterpenoid grimaldone has been synthesised using a formal [3+2] cycloaddition reaction as the key step. Subsequent transformation of the intermediate using ring-contraction methodology developed by House failed. Therefore, a new route to grimaldone was devised involving a modified Sharpless oxidative cleavage reaction. Again, an advanced intermediate was attained and model studies on that compound have indicated that a very late-stage precursor to grimaldone can be accessed relatively easily.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available