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Title: Mitogenic signalling by the endothelin receptor in Rat-1 fibroblasts
Author: MacNulty, Elisabeth E.
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1992
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Endothelin-1 (ET-1) was found to be a complete mitogen in Rat-1 fibroblasts and therefore the signalling pathways which might mediate its action were investigated. ET-1 stimulated both sustained phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylcholine (PtdCho) hydrolysis. The rank order of potency for both pathways stimulated by a range of ET isopeptides was the same for both responses (ET-1 ~ ET-2 > ET-3) suggesting that the same receptor controls both signalling pathways. PtdCho hydrolysis occurred kinetically downstream of Ptdlns(4,5)p2 hydrolysis by a phospholipase D-catalysed mechanism apparently involving both protein kinase C-dependent and -independent means of activation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available