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Title: Partial synthesis of novel trichothecene mycotoxins
Author: Thomas, Gerard Hugh
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1992
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The partial syntheses of two novel trichotheoene homologues, (13R)-3alpha,4beta, 15-triacetoxy-13-methyl-12,13-epoxy trichothec-9-ene (11) and (13S)-3alpha,4beta-triacetoxy-13-methyl-12,13-epoxytrichothec-9-ene (12), from the readily available trichothecenes DAS (1) (4beta,15-diacetoxy-3alpha-hydroxy-12,13-epoxytrichothec-9-ene) and MAS (2) (3alpha,15-dihydroxy-4beta-acetoxy-12,13-epoxytrichothec-9-ene) are detailed. These were carried out in order to provide further insight into the mode of action of the trichothecene mycotoxins. In addition, a model study was conducted which involved the synthesis of the bicyclo[3.2.1]octane epoxy alcohol (96) and the bicyclo[3.2.1]octane epoxy triethylsilyl ethers (110) and (111) from 2-methyl cyclohexanone.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available