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Title: Neuro-endocrine activation and inhibition in heart failure
Author: Cleland, John George Franklin
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1991
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The idea of vasodilator therapy for heart failure has been toyed with for almost one hundred years, possibly more. In the mid-twentieth century nitrates attained a definite role in the management of acute pulmonary oedema. There is little doubt that vasodilators can improve central haemodynamics acutely. However, during the 1970's investigators started to apply physiological principles of preload and afterload reduction to the management of chronic heart failure. The results were largely disappointing, either because tolerance occurred to the vasodilator actions of the drugs, or because vasodilatation is an ineffective mode of treatment for chronic heart failure. When work on this thesis started disillusionment was setting in regarding the efficacy of chronic vasodilator therapy for patients with heart failure.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available