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Title: G-proteins in N.I.D.D.M. and hypertension
Author: McLellan, Alastair Robert
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1991
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G-proteins are guanine-nucleotide-binding regulatory proteins which couple receptors to effector mechanisms; G-protein associated 'second messengers' include cAMP and the phospho-inositides, while other G-proteins are coupled to calcium and potassium channels. The expanding G-protein family (all of which share a common trimeric structure) currently includes at least 12 distinct G-proteins some of which can be identified in plasma membranes using specific antibodies (Western immuno-blotting): antibodies are available against several a subunits (Gsa, Gia1, Gia2, Gia3 and Goa)(which possess receptor and effector binding sites) as well as against B subunits. Function has not yet been ascribed to all G-proteins, but Gsa and Gia2 are concerned with the dual regulation (respectively stimulating and inhibiting) of adenylyl cyclase (AC) catalytic unit activity (A).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available