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Title: Isolation and characterisation of E. coli xerC, a gene required for cer site-specific recombination
Author: Colloms, Sean David
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1990
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The formation of plasmid multimers by homologous recombination can greatly reduce the heritable stability of the natural multicopy plasmid ColE1. ColE1 carries a 250 bp site (cer) which, when present in direct repeat (as in a ColE1 dimer) efficiently resolves plasmid multimers to momomers. cer-mediated monomerisation is strongly correlated with an increase in plasmid stability. Current evidence suggests that ColE1 segregates randomly at cell division, and that cer-dependent monomerisation ensures stability by increasing the number of independently segregating plasmid copies (Sherratt et a 7, 1984; Summers and Sherratt, 1984).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available