Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.796319
Title: Hepatocytes and nonregenerative hepatocyte cytosol in the treatment of acute hepatic failure
Author: Buist, Laura Jane
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1990
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Abstract:
Fulminant hepatic failure is a condition associated with a high mortality. The experience of its treatment over a 26 month period in a referral unit for acute liver failure is reviewed. The overall mortality rate was 45% but for those who progressed to grade IV hepatic coma the mortality rate was 73%. These figures represent the results of a combination of medical management and liver transplantation. The largest group of patients referred had developed liver failure due to ingestion of paracetamol (55%), the next largest group had viral hepatitis, mainly non A non B hepatitis (25%) and the others had an assortment of aetiologies including acute Budd-Chiari syndrome and other drug reactions. These different aetiological groups have been considered separately and predictors of outcome determined from their admission and early clinical and laboratory results. In the paracetamol group degree of coma, bilirubin and creatinine levels, hydrogen ion concentration and prothrombin ratio proved to be useful prognostic indicators but in the other two groups these measurements bore no relationship to the ultimate outcome.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.796319  DOI: Not available
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