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Title: Characterization and cloning of MHC class I sequences from choriocarcinoma JEG-3 cells
Author: Ward, Joanne
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1989
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The use of sera and monoclonal antibodies has permitted the serological definition of three polymorphic genetic loci HLA-A, HLA-B, and HLA-C, which encode the 45kDa heavy chains of the classical class I transplantation antigens. These molecules were identified because they elicited strong allograft rejection. Their true function is to serve as restriction elements by presenting peptidic antigens for recognition by cytotoxic T lymphocytes in MHC restricted responses. Molecular genetic analyses revealed that the vertebrate class I gene family was larger than expected, and there is evidence that at least some of these genes encode polypeptides whose structure and perhaps function is different from those of the classical class I loci.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available