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Title: Alteration of the small cell lung cancer phenotype and its effect on chemosensitivity
Author: Murray, Alison M. B.
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1989
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Small cell lung cancer (SCLC) accounts for approximately 25% of all lung cancers. It is distinguished from other lung cancers by the presence of neurosecretory granules, frequent peptide secretion, high levels of L-DOPA decarboxylase (DDC), creatine kinase BB isoenzyme (CKBB) ,neurone specific enolase (NSE) and bombesin-like immunoreactivity (BLI). It is a particularly aggressive neoplasm which has the potential for early metastatic dissemination, and by the time of diagnosis metastatic spread is often extensive. Consequently, surgical removal of the tumour is in most cases unlikely to result in a cure from the disease and chemotherapy is the most important treatment modality for SCLC. The eventual goal in the treatment of SCLC is to develop effective systemic therapy that will produce high response rates and a high percentage of long term disease-free survivors (cures).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available