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Title: Studies of Raney nickel-catalysed asymmetric hydrogenation reactions
Author: Christie, Sheena
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1988
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The hydrogenation of the prochiral beta-keto ester, methyl acetoacetate, to the beta-hydroxy ester, methyl 3-hydroxy butyrate, has been studied in some detail, using Raney nickel catalysts which have previously been treated with an optically active stereoisomer of tartaric acid. Various physical methods for the separation of the two enantiomers of the chiral reaction product have been investigated and the results are reported, together with a brief summary of recent developments in this field. Variations in the reaction conditions and the methods of catalyst preparation and modification have been found to exert a considerable influence on the conversion and enantioselectivity obtained during reactions. As a consequence of carrying out extensive series of investigations, the conditions which result in maximum conversion and optimum enantiomeric excess have been identified.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available