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Title: Serotonin and serotonergic type-2 antagonists in hypertension and adult atopic asthma
Author: Stott, David James
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1988
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Serotonin is a naturally occuring amine with vaso-active properties; its role in the pathogenesis of hypertension is unknown. Serotonin in blood is stored in platelets, and is released during platelet aggregation. Normally, only negligable amounts of serotonin are present in the plasma. Platelets from patients with untreated essential hypertension (n=22) showed increased serotonin-induced aggregation in whole blood in-vitro compared to age and sex matched normotensive controls (n=20). Enhanced platelet aggregation could contribute to raised arterial pressure in hypertension, by increasing free plasma levels of vasoconstrictors such as serotonin. However, spontaneous platelet aggregation in whole blood was not enhanced in these hypertensive patients.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available