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Title: The effects of p21 N-ras overexpression on the proliferation and transformation of NIH3T3 cells and its role in cellular signalling
Author: Davies, Shireen-Anne
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1988
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The ras oncogene family has been implicated in the growth and development of a high percentage of human tumours. However, the biochemical role of p21 ras the protein encoded by this oncogene, is not well defined. Therefore, the effects of p21 ras transformation of murine fibroblasts on cellular signal transduction were investigated. The study utilised a clone of NIH3T3 cells which overexpressed the p21 N-ras protooncogene in the presence of a glucocorticoid inducer. Overexpression of p21 N-ras in this cell line results in uncontrolled cell proliferation and transformation. The effects of transformation on growth factor mediated signal transduction pathways were studied.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available