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Title: Dopamine receptor subtypes : influences on local cerebral blood flow and function-related glucose utilisation
Author: Sharkey, John
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1986
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In recent years, two pharmacologically distinct subpopulations of dopamine receptor, designated and D2 have been found in brain and vascular tissue. The development of new classes of chemical compounds which discriminate between the subpopulations of dopamine receptor now permits the examination of dopaminergic mechanisms with a precision hitherto impossible. Of these, the benzazepine derivative SKF 38393 possesses a high degree of selectivity for the receptor while the partial ergoline LY 141865 (or as its biologically active enantiomer LY 171555) is a selective D2 agonist. These agents have been used extensively to examine anatomical distribution and neurochemical properties of the and D2 subpopulations in vitro. However, little is known about the effects of pharmacological manipulation of the and D2 receptor subpopulations upon the integrated activity of the brain in vivo.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available