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Title: Studies in cycloheptenes
Author: McCrae, James McGenchie
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1966
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Part I. Chapter 1 describes a synthesis of the colchicine skeleton, namely, desmethoxydesacetamido-8,9,10,11,12-hexahydrocolchicine. This was accomplished by utilising the bridge-cleavage reaction of a bicyclo-(3,2,1)-octan-8-one to the cycloheptene carboxylic acid. The acid produced was elaborated, via its methyl ketone to an 0-acetate which on reduction, yielded the above alcohol. In chapter 2 this cleavage reaction was employed in an unambiguous and selective synthesis of beta-carboxytropolone.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available