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Title: Synthetic approaches to naturally occurring cyclopentanes
Author: Clayton, John Peter
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1966
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PART I. Five synthetic routes to the prostaglandins, a group of highly substituted cyclopentanes, have been explored. The first four routes were unsuccessful but have provided interesting and useful information on a variety of substituted cyclopentanes. The fifth route has resulted in the isolation of 2-(6-cyanohexyl)-3-(oct-l-yn-3-ol) cyclopent-2-enone. The transformation of this important intermediate into the prostaglandin structure requires three further structural changes - the hydrolysis of the nitrile group, the selective reduction of the enyne system to a trans double bond and the introduction of a second oxygen function into the cyclopentane ring.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available