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Title: Clinical and laboratory aspects of salicylate therapy
Author: Bruce, James
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1953
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1. The literature on the pharmacology of sodium salicylate in rheumatism is reviewed. 2. An investigation of Brodie's (1944) method of measuring the salicylate content of serum is reported, and certain practical precautions described. 3. A number of general factors affecting serum salicylate concentrations were investigated, and the effect of administering different amounts of sodium salicylate at different frequencies and by different routes have been studied. 4. The effect of sodium bicarbonate administration on serum salicylate concentrations under different conditions of fluid intake has been studied. 5. The level of serum salicylate attained in certain diseases under standard conditions of dosage has been investigated. 6. The duration and incidence of certain manifestations of salicylism in subjects in whom various serum salicylate concentrations were being maintained is described. 7. The effect of sodium salicylate on the prothrombin activity of the plasma in vivo was studied in normal subjects, a series of individuals under treatment for a variety of conditions, and a series of patient suffering from ascorbic acid deficiency in varying degrees. 8. The effect of vitamin K administration, with and without ascorbic acid administration, on the hypoprothrombin-aemia caused by salicylate therapy is reported.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available