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Title: On the eosinophil leucocyte
Author: Vaughn, John
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1951
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1. The early history of the eosinophil leucocyte has been briefly presented with a review of the numerous suggestions made in the past concerning its nature and function. 2. A short account is given of the clinical occurrence and the experimental production of eosinophilia. 3. From Ascaris suum extracts have been prepared and their ability to produce eosinophilia in guinea pigs denonstrated. 4. The mode of action of these extracts has been investigated with reference to the part played by the sympathetic and parasympathetic nervous systems. 5. An unsuccessful search has been made for an eosinophilogenic substance in the blood of guinea pigs after an injection of extract. 6. The effect on the eosinophilogenic property of an extract of incubation with eosinophil leucocytes and other blood elements, and the action of chemical and physical agents has been observed. 7. The blood and tissue changes taking place in the guinea pig following an injection of extract have been closely studied and the probable path of the eosinophil leucocyte through the body traced. 8. The eosinophilogenic effect of histamine in guinea pigs has been demonstrated and some of the tissue changes following death by this drug recorded. 9. A limited investigation of the chemical properties of the extracts has been carried out. 10. Conclusions as to the nature of the stimulus of eosinophil formation and the function and fate of this cell have been drawn.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available