Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.794846
Title: Investigating the role of the mRNA capping enzymes in mouse embryonic stem cells and differentiation
Author: Clara Silva, Joana
ISNI:       0000 0004 8501 2878
Awarding Body: University of Dundee
Current Institution: University of Dundee
Date of Award: 2020
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Abstract:
The mRNA cap consists of a series of co-transcriptional modifications on nascent transcripts that confer protection from degradation and mediate RNA processing and translation. The addition of an inverted guanosine cap to the 5'-end of the transcript and its subsequent methylation along with the methylation of the first and second transcribed nucleotides are catalysed by several enzymes to form a complete cap structure. Growing evidence suggests that the mRNA cap and the mRNA capping enzymes can be regulated in a context-dependent manner by different molecules and signalling pathways either through co-factors or posttranslational modifications.
Supervisor: Cowling, Victoria Sponsor: Wellcome Trust
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.794846  DOI: Not available
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