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Title: Light-activated caged iron chelators (CICs) for skin photoprotection
Author: Hampshire, Annabel
ISNI:       0000 0004 8499 5286
Awarding Body: University of Bath
Current Institution: University of Bath
Date of Award: 2019
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UV radiation from the sun to which the skin is exposed is largely UVA. UVA is oxidative in nature and may generate redox-active labile iron within skin cells, inducing severe damage through the production of reactive oxygen species (ROS), and leading to skin photoaging and cancer. Light-activated caged iron chelators (CICs) are compounds that become active when exposed to environmentally relevant doses of UVA, releasing a potent iron-trapping agent or chelator, and providing UVA dose-dependent protection from harmful labile iron.
Supervisor: Eggleston, Ian ; Pourzand, Charareh Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: UVA ; Labile iron ; Iron chelator ; Photoprotection