Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.793388
Title: Engineering composite particles to overcome the poor pharmaceutical performance of paracetamol
Author: Rose, Ayuk Agbor
ISNI:       0000 0004 8502 7092
Awarding Body: University of Wolverhampton
Current Institution: University of Wolverhampton
Date of Award: 2019
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Abstract:
Tablets are the most common solid dosage forms because of their several advantages including the ease of administration, precise dosing, ease of manufacturing, good product stability in comparison to liquids, and tamper-proofness in comparison to capsules. Direct compression is the favoured smart choice for tablet manufacturing. The advantages of direct compression: include simplicity, reduced time and the final cost of the product due to fewer processing stages, continuous nature, and elimination of heat and moisture effects, making direct compression an appropriate process for hygroscopic and thermo-sensitive materials. However, it is unfortunate that only less than ~20% of pharmaceutical powders can be compressed into tablets by direct compression due to their inherent poor functional properties required for direct compression. The situation is particularly severe when a high dose of a poorly compactible drug such as paracetamol must be used. Paracetamol is a widely used analgesic drug. The monoclinic form is usually selected in the pharmaceutical industry and is the commercially available form because it is thermodynamically stable at room temperature and pressure. However, the monoclinic form of paracetamol is notorious for exhibiting poor tableting properties by direct compression, reduced plastic deformation during compression, commonly resulting in fragile tablets with a high propensity to cap. This work commences by providing insights into how, current and innovative processing techniques, parameters (milling time, temperature and solvents), and the combination of drugs and/or excipient impact the mechanical properties of paracetamol. The mechanical properties were investigated by applying blending, freeze drying, milling, batch cooling crystallisation, solvent evaporation and cocrystals formation, while, modifying the physicochemical structure of paracetamol crystals to improve tabletability was the rationale. The modified particles, with the desired behaviour acquired, were characterised using FT−IR, PXRD, laser diffraction, SEM, DSC, TGA, Water absorption profile, flowability, stability, content uniformity, dissolution and tabletability. Tabletabilty data demonstrated an immerse enhancement in the drug's tensile strength upon processing using different blending energy (~8 folds) and preparation techniques (~11 folds), various freezing temperatures (~12 folds) with the polymer polyvinylpyrrolidone using various drugs such as Ibuprofen (~5 folds), aspirin and caffeine (~9 folds), Curcumin (~9 folds) chondroitin sulphate A (~11 folds) and cocrystals with the coformer 5-Nitroisophthalic acid (~12 folds). Regardless, of the co-processing techniques applied with paracetamol in the presence of other drugs and excipient, there was an improvement of the tablettabililty of paracetamol in comparison to the drug alone. In conclusion, the co-engineering of poorly compactable model drug chosen paracetamol with other drugs and excipient influenced the mechanical properties of paracetamol without changes in crystallinity and polymorphic structure.
Supervisor: Kaialy, Waseem Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.793388  DOI: Not available
Keywords: direct compression ; crystal size ; crystal habit ; crystallinity ; electrostatic interaction ; interactive mixtures ; hydrogen bonding ; physicochemical properties ; Tableting ; Mechanical properties
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