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Title: Towards mitochondrial targeting for the treatment of Alzheimer's Disease
Author: Abdul Razzak, Rana
ISNI:       0000 0004 8502 4609
Awarding Body: University of St Andrews
Current Institution: University of St Andrews
Date of Award: 2019
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Nanoparticles (NPs) have emerged as a promising approach to overcoming biological barriers imposed by the human body. Polymeric NPs offer a superior synthetic flexibility and advances in polymerization chemistries have made polymeric architectures with precisely tuned properties accessible. Ring opening metathesis polymerization (ROMP) has become a popular polymerization technique due to its mild conditions a tolerance to an array of functional groups. We successfully synthesized two generations of ROMP monomers that feature polymerizable group and a mitochondrial targeting ligand linked together via a hydrophilic spacer. This monomer can be co-polymerized with another ROMP monomer bearing a fluorescent molecule to enable the visualization of the polymeric NPs in the cell. The second-generation monomers differ from the first-generation analogues by their three-fold longer hydrophilic linkers. Co-polymers prepared from second-generation monomers show cellular up-take but no mitochondrial localization.
Supervisor: Florence, Gordon John ; Gunn-Moore, Frank J. Sponsor: University of St Andrews ; St Andrews Education for Palestinian Students (STEPS)
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral