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Title: A combined experimental and computational framework to optimise processing and design of poly(L-lactic acid) bioresorbable stents
Author: Blair, Ross
ISNI:       0000 0004 8504 2188
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2019
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Coronary heart disease, caused by inflammatory hardening and narrowing of arteries (atherosclerosis) is the largest cause of death in the world. Coronary stents, used to treat atherosclerosis, are typically manufactured from high strength metallic alloys; however such devices remain in the body permanently and can trigger undesirable immunological responses. Bioresorbable polymer stents offer an attractive solution, providing a temporary scaffold that resorbs once the artery heals. However, polymeric stents are mechanically inferior to their metallic counterparts, requiring thicker struts to provide equivalent radial support, which has been shown to cause elevated rates of thrombosis. This thesis aims to address the challenge of designing mechanically effective but sufficiently thin bioresorbable polymer stents through multi-objective optimisation of material parameters and stent geometry.
Supervisor: Menary, Gary ; Lennon, Alexander Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: coronary stents ; poly(L-lactic acid) ; biaxial stretching ; constitutive modelling ; multi-objective optimisation