Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.791696
Title: Insights into mechanisms and clinical implications of myocardial fibrosis and its progression in hypertrophic cardiomyopathy
Author: Raman, Betty
ISNI:       0000 0004 8503 089X
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2019
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Abstract:
Hypertrophic cardiomyopathy (HCM), the most common inherited cardiomyopathy, is both phenotypically and clinically diverse. Sudden cardiac death is a devastating and feared complication of this disease but remains difficult to predict because of the vast heterogeneity seen in disease expression. The need to better identify individuals at risk of fatal arrhythmic events has led to the quest for more powerful and sensitive markers of risk. Myocardial fibrosis is one such marker and believed to be an important substrate capable of promoting fatal arrhythmic events. Studies have shown that myocardial fibrosis can be progressive; however, the clinical significance of progressive disease and underlying causal mechanisms remain unclear. This thesis sought to examine the underlying mechanisms and prognostic significance of fibrosis progression in HCM patients and draws insights from a set of studies that use advanced cardiac magnetic resonance techniques to probe deeper into disease pathophysiology.
Supervisor: Neubauer, Stefan ; Mahmod, Masliza ; Watkins, Hugh Sponsor: British Heart Foundation ; NIHR Oxford Biomedical Research Centre
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.791696  DOI: Not available
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