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Title: Diffusion MRI in premanifest Huntington's disease and early Parkinson's disease : tensor and tractography analyses
Author: Pflanz, Chris Patrick
ISNI:       0000 0004 8502 9354
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2019
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Huntington's and Parkinson's disease are neurodegenerative movement disorders that both affect the basal ganglia, a system of interconnected deep cerebral nuclei that receive converging input from various cortical areas through white matter tracts. Here we have used diffusion MRI to investigate changes in the tissue microstructure of the basal ganglia, as well as the white matter in presymptomatic/early Huntington's and early Parkinson's disease. In the presymptomatic Huntington's disease group longitudinal sensitivity of diffusion MRI across presymptomatic stages was investigated. We also have investigated the connectivity of the basal ganglia with the cortex, and derived connectivity-based parcellations of the gobus pallidus, and subthalamic nucleus, two important hubs of the basal ganglia system, into motor, limbic, and associative territories. In presymptomatic Huntington's disease distinct longitudinal changes in the microstructure of the posterior part of the basal ganglia and the splenium of the corpus callosum, as revealed by diffusion tensor metrics, were detectable at different presymptomatic stages. Both patients with Huntington's and Parkinson's disease showed micro-structural alterations in the internal segment of the globus pallidus,and the posterior limb of the internal capsule, two important neuroanatomical structures of the basal ganglia system. Huntington's disease patients also showed marked decreases in their structural connectivity in the motor basal ganglia pathway, and the cortico-subthalamic hyperdirect pathway. The volumes of connectivity-based territories of the globus pallidus, pars interna, and subthalamic nucleus undergo disease-specific alterations that capture opposing effects in Huntington's vs. Parkinson's disease. Connectivity-based territories undergo disease-related changes in their coordinates that might be of clinical importance. Neuroimaging outcomes were found to be correlated with clinical questionnaire data.
Supervisor: Douaud, Gwenaelle ; Jenkinson, Mark Sponsor: Engineering and Physical Sciences Research Council (EPSRC) ; Medical Research Council (MRC)
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Clinical Neuroimaging