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Title: Neuroimaging markers of motor function in children with cerebral palsy
Author: Soskic, Sonja
ISNI:       0000 0004 8500 5715
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2019
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Cerebral palsy (CP) is one of the most common causes of childhood physical disability. Despite extensive research, brain structure-motor function relationships are yet to be fully established. The aim of this thesis was to use advanced diffusion MRI and an individualised approach in a small heterogeneous group of children with CP to identify and quantify changes in brain structure that are consistent and related to measures of sensorimotor function. The following analyses were employed: connectivity-based parcellation of subcortical structures, assessment of diffusion parameters of subcortical structures, and evaluation of white matter pathways involved in sensorimotor function using tractography, diffusion tensor imaging and advanced diffusion models. Overall, the findings of this thesis indicate that properties of structures and pathways assessed at the level of the brainstem and cerebellum may be closely related to measures of motor function in children with CP. These findings could provide guidance for future larger studies aiming to establish clinically useful imaging markers of motor function in patients with CP.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available