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Title: Focal high intensity focused ultrasound in the treatment of non-metastatic prostate cancer
Author: Guillaumier, Stephanie
ISNI:       0000 0004 8500 1407
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2019
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Introduction: This thesis will explore the adverse events, side-effect profile and efficacy of high intensity focused ultrasound to treat non-metastatic prostate cancer. I will look at the background of prostate cancer and how advances in the diagnostic pathway for prostate cancer, as well as the paradigm shifts in treatment for this disease, have defined the current treatment landscape for localized prostate cancer and how focal therapy fits in. Objectives: The aim of this thesis is to evaluate the efficacy and medium-term outcomes of focal HIFU from a multicentre registry of over 600 cases treated over the last 10 years in the UK. In so doing, this thesis will explore the use of registries in defining novel treatments as a useful body of evidence that might be used to impact on standard care in the absence of randomized controlled studies which are difficult to conduct within surgical specialties. The future role of focal therapy and high intensity focused ultrasound will be discussed, providing insights into the evolution of this ablative therapy, and how it might take its place within the armamentarium of treatments available for localized prostate cancer. Results: The multicenter academic focal HIFU registry demonstrates acceptable oncological control in men diagnosed with non-metastatic prostate cancer is achievable with acceptable o Conclusions The medium-term data presented in this thesis is the first of its kind and supports the contention that focal therapy has a role in decreasing the genito-urinary side-effects associated with standard whole-gland therapies. Trifecta status of leak-free, pad-free continence, erections sufficient for intercourse, and oncological control is achievable with focal HIFU with acceptable results. Ultimately, long-term data will be necessary, including 5 research into comparative effectiveness to further establish the future role of focal therapy in treating localized prostate cancer.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available