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Title: Neural correlates of inhibition in children and adolescents with conduct problems : an exploration of treatment effects following multisystemic therapy
Author: Hanley, J. E.
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2016
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AIMS: This study aimed to explore the neural correlates of inhibition in children and adolescents with histories of behaviour problems using Event Related Potentials (ERPs). Comparisons were made between clinical and control groups and between Multisystemic Therapy (MST) and Treatment as Usual (TAU) treatment groups. Finally, treatment improvers were compared with non-improvers to determine whether inhibitory ERPs reflect treatment effects. Additionally, the study examined how different levels of a social provocation condition influenced the inhibitory ERPS. METHODS: Two clinical groups, MST (n=30) and TAU (n=30), and a control group (n=33), completed a go/no-go task while ERPs were recorded. The go/no-go task involved a social-competitive aspect whereby they played against other young people (actually a computer program) and the impact of being provoked (financially punished) harshly or leniently was explored. Clinical participants completed a self report delinquency measure and this was used to determine improver status. RESULTS: No main effects group differences were found for clinical versus control, or MST vs TAU, or improvers vs improvers. There was however a significant interaction between gender, group, and go-no go that was seen in both clinical/control and MST/TAU comparisons. Male clinical (and male TAU) participants were found to have a larger difference between no-go and go P3 amplitudes. CONCLUSIONS: No evidence was found to support the idea that ERPs of inhibition can distinguish childhood conduct disorder or index treatment related changes. This finding is discussed in relation to research on other externalising conditions. The finding that P3 showed an interaction for gender, group, and go/nogo was suggested to reflect motivational/engagement factors that may have resulted from the task design.
Supervisor: Fearon, P. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available