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Title: Gene dosage and the evolution of gene expression
Author: Zimmer, F.
ISNI:       0000 0004 8497 8363
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2016
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The duplication and loss of genes, chromosomes and whole genomes has had a major impact on the evolution of most organisms. Changes in gene copy number, called gene dosage, may influence the resulting level of gene product through changes in gene expression. These gene expression changes can be detrimental, resulting in compensation and buffering mechanisms, or beneficial, when selection favours increased gene dosage. Understanding how changes in gene dose can influence the evolution of gene expression within and between species is an important task in evolutionary biology. This thesis combines studies of gene, protein domain, and genome duplications with gene expression data from a range of bird species to understand the evolutionary consequences of gene dosage changes. In addition to gene duplication and loss events, the genomic location of genes can subject loci to different evolutionary pressures. Genes present on sex chromosomes or the mitochondria are inherited unequally between males and females, potentially causing sexual conflict over expression. This thesis investigates if inter-genomic conflict could drive gene movement on and off the sex chromosomes using a comparative genomics approach.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available