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Title: Electrical impedance tomography of fast neural activity in the brain
Author: Ghosh, A.
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2015
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Electrical impedance tomography (EIT) is a recently developed imaging method that can be used to reconstruct the internal conductivity of a body from boundary measurements. A proposed application of EIT within head imaging is functional brain imaging. The work of this thesis was aimed specifically at producing images of fast neuronal depolarisation in the brain. Chapter 1 is a review of other brain imaging techniques, the principles of EIT and bioimpedance and nerve physiology. Chapter 2 was a study to verify previous work on measuring the impedance change in unmyelinated crab nerves using a DC carrier. Chapter 3 was a study aimed at using a low frequency sinusoidal wave carrier to do the same and in chapter 4 the same carrier was used to measure the impedance change during evoked responses on the anaesthetised rat cerebral cortex and identify the optimum frequency and current to be used to reconstruct images. Chapter 5 details experiments to image fast neuronal activity in rat cerebral cortex of different evoked sensory modalities (vibrissae, forepaw, hindpaw sensation and visual responses) using the above carrier.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available