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Title: Modelling the inhibitory components of the interleukin-1β network
Author: Kelsey, J.
Awarding Body: University College London
Current Institution: University College London (University of London)
Date of Award: 2012
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The inhibitory influences present in the interleukin-1β network are considered, and their effect on the network elucidated. IL-1β is a pro-inflammatory cytokine essential to the functioning of the immune system. The IL-1 network exhibits a complexity which has been noted by many researchers. It exists in two forms, α and β, which afforded a natural way of drawing a boundary around which part of the network was to be modelled: a choice between the α or β forms. The β form was chosen for investigation since it is known to have a higher potency than the α form. IL-1β requires the formation of a signalling ternary complex in order to trigger signalling transduction; it needs to bind with the signalling (Type-I) receptor, and for this binary complex in turn to be bound by a receptor acces- sory protein, before signalling transduction can proceed. A variety of control mechanisms which inhibit the formation of this signalling ternary process have evolved. These have been modelled using a variety of techniques.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available