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Title: Novel approaches to drug development by applications of Accelerator Mass Spectrometry
Author: Young, Graeme
ISNI:       0000 0004 8501 5008
Awarding Body: University of Lincoln
Current Institution: University of Lincoln
Date of Award: 2016
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Accelerator Mass Spectrometry (AMS) is an extremely sensitive nuclear physics isotope ratio technique with growing application to clinical pharmaceutical drug development. The papers discussed in this commentary demonstrate a wide variety of clinical study designs that incorporate the use of radiocarbon ( 14C) as a tracer, with subsequent analysis by AMS. The focus of the commentary is application of AMS as an enabling technique aimed towards novel investigations of the absorption, distribution, metabolism, excretion and pharmacokinetics (ADME-PK) of new therapeutic drugs in humans. The impact and contributions to this field of research are demonstrated through discussion and critical examination of selected examples of the author's peerreviewed publications in this area. The first use of AMS in a clinical study for a new drug in development is included, along with other ADME-PK studies with potential new medicines. The commentary details the expanding scope of AMS over recent years to encompass experiments designed to yield previously unattainable data. Developments of scientific practices, where the author has contributed intellectual, leadership and practical insight to achieve significant improvements in the generation of knowledge, are highlighted throughout the commentary. The ongoing and future development of AMS, as well as the emergence of techniques as potential alternatives to AMS to provide deep insight into the research of new medicines are also discussed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available