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Title: An investigation of heredity in the aetiology and pathogenesis of cleft palate and of cleft lip and palate
Author: Mossey, Peter Anthony
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1994
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Cleft lip with or without cleft palate (CL(P)) and isolated cleft palate (CP) are caused by primary defects in the fusion of craniofacial processes that form the primary and secondary palate respectively. CL(P) and CP are considered to be separate diagnostic entities and for both multifactorial inheritance has been proposed, although the precise roles played by genes, environment and chance are unclear; and in particular the nature and number of genes involved is not known. The aim of this study was to try to identify parental characteristics (genotypic or phenotypic) which were associated with an increased risk of having a child with CL(P) or CP. The combination of phenotypic and genotypic data can improve the ability to predict parental predisposition towards CP or CL(P) beyond the predictive ability of either cephalometric or genetic data in isolation. The lack of correlation between these genotypes and the cephalometric parameters would suggest that other genetic loci are involved in the predisposition to CL(P) and CP and further analysis of other candidate genes using this approach would merit consideration.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available