Use this URL to cite or link to this record in EThOS:
Title: Synthesis of novel organic conductors and physical and chemical investigation of some cyclic systems
Author: Maguire, John
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1994
Availability of Full Text:
Access from EThOS:
Access from Institution:
Different aromatic systems have been synthesised with the aim of generating new conducting organic molecules. These molecules either incorporate heterocyclic atoms, sulphur or selenium, or are based on a donought shaped system. Both systems depend on extensive delocalisation to facilitate, with or without d-orbital enhancement, the electron movement. To investigate the alpha effect the synthesis of an oxetane was attempted using various routes and strategies. The initial Diels-Alder reactions led to various attempts to synthesise the key intermediate, 7,7-dimethylnorbornadiene. Artemisinin is an antimalarial drug, effective against Plasmodium falciparum, that chemically combats the the parasite in a different mode from traditional drugs. The synthesis of simple analogues was investigated to show that the activity was attributed to the peroxide bridge and that other functionalities present served to enhance this property. As a result of NMR studies on various Schiff's Base systems it was shown that the formation of a molecular complex, as reported by the authors, was incorrect and a Schiff's Base reaction had occurred between the solute and acetone. The influence of electron withdrawing substituents on the chemical shift of 4-substituted camphors has been investigated and the results reported.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available